Effects of Lithium Therapy on Ventricular Repolarization in Bipolar Disorder Patients

Clicks: 188
ID: 105610
2018
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Introduction: Bipolar disorder (BD) is a significant mental health concern in the world. Most of the drugs used in the treatment of bipolar disease may cause life-threatening arrhythmias by affecting the distribution of ventricular repolarization (VR). VR is commonly assessed using QT interval and Twave measurements. The aim of this study was to evaluate VR using the T peak to T end (Tp-e) interval and the Tp-e/QT ratio and to investigate the relationship between lithium therapy and VR parameters in patients with BD. Patients and Methods: Forty-six BD patients under lithium therapy and 45 participants in a control group were included in our study. The Tp-e interval and Tp-e/QT ratio were measured using 12derivation electrocardiography (ECG). These parameters were compared between groups. Results: The QT interval (p= 0.01), QTc interval (p= 0.003), Tp-e interval (p< 0.001), and Tpe/QT ratio (p= 0.009) were significantly higher in patients with BD than in the control group. There was a positive correlation between the Tp-e interval and serum lithium levels (r= 0.317, p< 0.032). In addition, the increased serum lithium level (β= 0.398, p= 0.007) was found to be an independent predictor of the prolonged Tp-e interval. Conclusion: Prolonged Tp-e interval may be a useful indicator of increased risk of ventricular arrhythmia in patients using lithium therapy.
Reference Key
zencir2018effectskosuyolu Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zencir, Cemil;Karakuş, Kadir;Kocabaş, Oktay;Bahtiyar, Gökhan;Selvi, Mithat;Karaman, Kayıhan;
Journal koşuyolu heart journal
Year 2018
DOI
DOI not found
URL
http://www.kosuyoluheartjournal.com/managete/fu_folder/2018-3/2018-21-3-193-197.pdf
Keywords
Microbiology Infectious and parasitic diseases Veterinary medicine Medicine (General) Medicine Engineering (General). Civil engineering (General) Agriculture (General) Diseases of the circulatory (Cardiovascular) system gynecology and obstetrics

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.