A model for gain of function in superoxide dismutase.

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ID: 105473
2020
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Abstract
Studies have found that mutant, misfolded superoxide dismutase [Cu-Zn] (SOD1) can convert wild type SOD1 (wtSOD1) in a prion-like fashion, and that misfolded wtSOD1 can be propagated by release and uptake of protein aggregates. In developing a prion-like mechanism for this propagation of SOD1 misfolding we have previously shown how enervation of the SOD1 electrostatic loop (ESL), caused by the formation of transient non-obligate SOD1 oligomers, can lead to an experimentally observed gain of interaction (GOI) that results in the formation of SOD1 amyloid-like filaments. It has also been shown that freedom of ESL motion is essential to catalytic function. This work investigates the possibility that restricting ESL mobility might not only compromise superoxide catalytic activity but also serve to promote the peroxidase activity of SOD1, thus implicating the formation of SOD1 oligomers in both protein misfolding and in protein oxidation.
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healy2020abiochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Healy, Eamonn F;Roth-Rodriguez, Analise;Toledo, Santiago;
Journal Biochemistry and biophysics reports
Year 2020
DOI
10.1016/j.bbrep.2020.100728
URL
Keywords
amyotrophic lateral sclerosis superoxide dismutase sod1 dismutase mechanism sod1 gain of function sod1 peroxidase mechanism

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