HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia.

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ID: 104735
2020
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Abstract
Russia has one of the largest and fastest growing HIV epidemics. However, epidemiological data are scarce. Sub-subtype A6 is most prevalent in Russia but its identification is challenging. We analysed protease/reverse transcriptase-, integrase-sequences, and epidemiological data from 303 patients to develop a methodology for the systematisation of A6 identification and to describe the HIV epidemiology in the Russian Southern Federal District. Drug consumption (32.0%) and heterosexual contact (27.1%) were the major reported transmission risks. This study successfully established the settings for systematic identification of A6 samples. Low frequency of subtype B (3.3%) and large prevalence of sub-subtype A6 (69.6%) and subtype G (23.4%) were detected. Transmitted PI- (8.8%) and NRTI-resistance (6.4%) were detected in therapy-naive patients. In therapy-experienced patients, 17.3% of the isolates showed resistance to PIs, 50.0% to NRTI, 39.2% to NNRTIs, and 9.5% to INSTIs. Multiresistance was identified in 52 isolates, 40 corresponding to two-class resistance and seven to three-class resistance. Two resistance-associated-mutations significantly associated to sub-subtype A6 samples: A62V and G190S. This study establishes the conditions for a systematic annotation of sub-subtype A6 to normalise epidemiological studies. Accurate knowledge on South Russian epidemiology will allow for the development of efficient regional frameworks for HIV-1 infection management.
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schlosser2020hiv1viruses Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Madita Schlösser, Vladimir V Kartashev, Visa H Mikkola, Andrey Shemshura, Sergey Saukhat, Dmitriy Kolpakov, Alexandr Suladze, Tatiana Tverdokhlebova, Katharina Hutt, Eva Heger, Elena Knops, Michael Böhm, Veronica Di Cristanziano, Rolf Kaiser, Anders Sönnerborg, Maurizio Zazzi, Marina Bobkova, Saleta Sierra
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Journal Viruses
Year 2020
DOI
E475
URL
Keywords
Drug resistance Epidemiology hiv russia subtyping a-fsu a6 idu-a

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