Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: application of the additive model for cancer

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ID: 104629
2011
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Abstract
Lung cancer is the leading cause of cancer mortality in Mexico and worldwide. In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. In this study, we genetically characterized 16 polymorphisms in 12 low penetrance genes (AhR, CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTPI, XRCC1, ERCC2, MGMT, CCND1 and TP53) in 382 healthy Mexican Mestizos as the first step in elucidating the genetic structure of this population and identifying high risk individuals. All of the genotypes analyzed were in Hardy-Weinberg equilibrium, but different degrees of linkage were observed for polymorphisms in the CYP1A1 and EPHX1 genes. The genetic variability of this population was distributed in six clusters that were defined based on their genetic characteristics. The use of a polygenic model to assess the additive effect of low penetrance risk alleles identified combinations of risk genotypes that could be useful in predicting a predisposition to lung cancer. Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV) ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer.
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Authors Pérez-Morales, Rebeca;Méndez-Ramírez, Ignacio;Castro-Hernández, Clementina;Martínez-Ramírez, Ollin C.;Gonsebatt, María Eugenia;Rubio, Julieta;
Journal Genetics and molecular biology
Year 2011
DOI
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URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400003
Keywords
Microbiology Infectious and parasitic diseases Biology (General) Medicine Science neoplasms. tumors. oncology. including cancer and carcinogens arctic medicine. tropical medicine genetics

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