Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4).

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ID: 104590
2020
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Ranked #11 of 320 articles by views in european journal of cancer prevention : the official journal of the european cancer prevention organisation (ecp)

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Abstract
The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies.To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy.We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. We estimated pooled odds ratios and the corresponding 95% confidence intervals by estimating study-specific odds ratios through multivariable unconditional logistic regression models, and then pooling the obtained estimates using fixed-effects models.Compared with patients with no history of gallbladder disease, the pooled odds ratio of pancreatic cancer was 1.69 (95% confidence interval, 1.51-1.88) for patients reporting a history of gallbladder disease. The odds ratio was 4.90 (95% confidence interval, 3.45-6.97) for gallbladder disease diagnosed <2 years before pancreatic cancer diagnosis and 1.11 (95% confidence interval, 0.96-1.29) when ≥2 years elapsed. The pooled odds ratio was 1.64 (95% confidence interval, 1.43-1.89) for patients who underwent cholecystectomy, as compared to those without cholecystectomy. The odds ratio was 7.00 (95% confidence interval, 4.13-11.86) for a surgery <2 years before pancreatic cancer diagnosis and 1.28 (95% confidence interval, 1.08-1.53) for a surgery ≥2 years before.There appears to be no long-term effect of gallbladder disease on pancreatic cancer risk, and at most a modest one for cholecystectomy. The strong short-term association can be explained by diagnostic bias and reverse causation.
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rosato2020gallbladdereuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rosato, Valentina;Negri, Eva;Bosetti, Cristina;Malats, Núria;Gomez-Rubio, Paulina;Consortium, PanGenEU;Maisonneuve, Patrick;Miller, Anthony B;Bueno-de-Mesquita, H Bas;Baghurst, Peter A;Zatonski, Witold;Petersen, Gloria M;Scelo, Ghislaine;Holcatova, Ivana;Fabianova, Eleonora;Serraino, Diego;Olson, Sara H;Vioque, Jesús;Lagiou, Pagona;Duell, Eric J;Boffetta, Paolo;La Vecchia, Carlo;
Journal european journal of cancer prevention : the official journal of the european cancer prevention organisation (ecp)
Year 2020
DOI
10.1097/CEJ.0000000000000572
URL
Keywords
Epidemiology pig envelope japanese encephalitis virus

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