Synthesis of promising antimicrobial agents: hydrazide-hydrazones of 5-nitrofuran-2-carboxylic acid.
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2020
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Abstract
In this research, we synthesized and evaluated for in vitro antimicrobial activity a new series of hydrazide-hydrazones obtained from 5-nitrofuran-2-carboxylic acid. New compounds were identified and characterized by spectral methods ( H NMR and C NMR). All tested hydrazide-hydrazones proved to be promising antimicrobial agents. Antimicrobial activity and antifungal activity of new derivatives of 5-nitrofuran-2-carboxylic acid were revealed in many cases to be higher than the activity of reference substances (nitrofurantoin, cefuroxime and ampicillin).
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popioek2020synthesischemical
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| Authors | Popiołek, Łukasz;Rysz, Bernadetta;Biernasiuk, Anna;Wujec, Monika; |
| Journal | Chemical biology & drug design |
| Year | 2020 |
| DOI |
10.1111/cbdd.13639
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