Synthesis of promising antimicrobial agents: hydrazide-hydrazones of 5-nitrofuran-2-carboxylic acid.

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ID: 104551
2020
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Abstract
In this research, we synthesized and evaluated for in vitro antimicrobial activity a new series of hydrazide-hydrazones obtained from 5-nitrofuran-2-carboxylic acid. New compounds were identified and characterized by spectral methods ( H NMR and C NMR). All tested hydrazide-hydrazones proved to be promising antimicrobial agents. Antimicrobial activity and antifungal activity of new derivatives of 5-nitrofuran-2-carboxylic acid were revealed in many cases to be higher than the activity of reference substances (nitrofurantoin, cefuroxime and ampicillin).
Reference Key
popioek2020synthesischemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Popiołek, Łukasz;Rysz, Bernadetta;Biernasiuk, Anna;Wujec, Monika;
Journal Chemical biology & drug design
Year 2020
DOI
10.1111/cbdd.13639
URL
Keywords
Antimicrobial cytotoxicity activity adamantane derivatives hydrazide-hydrazone

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