Synthesis, Spectroscopic, In-vitro and Computational analysis of hydrazones as potential antituberculosis agents: (Part-I).

Clicks: 432
ID: 104540
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #2 of 36 articles by views in combinatorial chemistry & high throughput screening

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Since last decades, the healthcare sector is facing the problem of development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections all over the world. Regardless of current healthcare progress for treatment of mycobacterial infections, we are still unable to control addition of every year 9 million new cases of tuberculosis (TB).We had objective to synthesize some novel hydrazones, which were further subjected to characterization, Photoluminescence study, in-vitro anti-mycobacterium testing and in-silico ADMET predictions.Some new hydrazone derivatives have been successfully prepared by the condensation reaction in the present study. All the compounds were characterized by using FTIR, NMR, UV, Fluorescence spectroscopic techniques.All our newly synthesized compounds showed strong electronic excitation at 292.6 - 319.0 nm and displayed more intense emissions in the 348 - 365 nm regions except compound 3i. The newly synthesized hydrazones 3a, 3b, 3f and 3g were found to be most active compounds and showed MIC (Minimum inhibitory concentrations) values of 12.5 μg/mL.In the realm of development of more potent, effective, safer and less toxic antituberculosis agents; our current study would definitely help the medicinal chemists to develop potent analogues containing hydrazine motifs in them.
Reference Key
thorat2020synthesiscombinatorial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thorat, Bapu R;Rani, Deepa;Yamgar, Ramesh S;Mali, Suraj N;
Journal combinatorial chemistry & high throughput screening
Year 2020
DOI
10.2174/1386207323999200325125858
URL
Keywords
synthesis tuberculosis antituberculosis activity hydrazide-hydrazones admet predictions. in-silico analysis

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.