pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [ F]Fluoromisonidazole.

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ID: 104537
2020
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Abstract
To improve the signal-to-noise ratio of hypoxia positron emission tomography (PET) imaging, stimuli-responsive polymers are designed for the delivery of the hypoxia PET tracer fluorine-18 labeled fluoromisonidazole ([ F]FMISO). Linear poly(N-(2-(hydroxypropyl)methacrylamide)) polymers are functionalized with hydrazide linkers that form pH-sensitive acyl hydrazone bonds after their conjugation to an [ F]FMISO ketone analogue. The release of the [ F]FMISO ketone analogue from the polymers is considerably faster at a lower pH and its uptake is significantly higher in cancer cells growing under acidic conditions. Additionally, the retention of the PET tracer is significantly higher in hypoxic cells compared to normoxic cells. The delivery of a PET tracer using stimuli-responsive polymers may be an attractive strategy to improve signal-to-noise ratios in PET imaging.
Reference Key
goos2020phresponsivemacromolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Goos, Jeroen A C M;Davydova, Maria;Lengkeek, Nigel;Greguric, Ivan;Whittaker, Michael R;Quinn, John F;Baell, Jonathan B;Lewis, Jason S;Davis, Thomas P;
Journal Macromolecular rapid communications
Year 2020
DOI
10.1002/marc.202000061
URL
Keywords
Hypoxia polymers fluoromisonidazole stimuli-responsive materials

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