Synthesis and Antimicrobial Activities of Some Novel Quinoxalinone Derivatives

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ID: 104532
2000
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Abstract
Condensation of 4-benzoyl-1,2-phenylenediamine with sodium pyruvate in acetic acid furnished two products which were identified as 6-benzoyl and 7-benzoyl-3-methyl-2(1H)quinoxalinones (1a,b). Fusion of 1a with aromatic aldehydes furnished the styryl derivatives 2a-c. Alkylation of 1a,b with dimethyl sulphate or ethyl chloroacetate produced the N-alkyl derivatives 3a,b and 4a,b. Hydrazinolysis of the ester derivative 4a with hydrazine hydrate afforded the hydrazide derivative 5 which underwent condensation with aldehydes to give the corresponding hydrazone derivatives 6a,b. In addition, chlorination of 1a with thionyl chloride afforded the 2-chloro derivative 7 which was subjected to reaction with sodium azide and n-butylamine to yield the corresponding tetrazolo (8) and n-butylamino (9) derivatives, respectively. The structures of the compounds prepared were confirmed by analytical and spectral data. Also, some of the synthesized compounds were screened for antimicrobial activity.
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ammar2000synthesismolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ammar, Y. A.;Zahran, M. A.;El-Gaby, M. S.A.;Ismail, M. M.F.;Ali, M. M.;
Journal molecules
Year 2000
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/5/6/864/
Keywords
chemistry Organic Chemistry Pharmacy and materia medica chemical engineering

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