Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease

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ID: 10453
2018
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Abstract
Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebral vascular motor reactivity in Alzheimer’s disease subjects and to associate these changes with their cognitive scores. Methods. We recruited subjects with a diagnosis of Alzheimer’s disease and healthy controls. Demographic, clinical, imaging, and cognitive test were obtained. Then all participants performed a cerebral vascular motor reactivity test with 7% CO2 and cerebral blood flow velocities (CBFV) were recorded with transcranial doppler ultrasound before and after the test. Results. We recruited 45 subjects, 26 (21 female) Alzheimer’s disease participants and 19 (15 female) healthy controls. There were no differences in baseline cerebral blood flow velocities between the groups. After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m) was 8.70±4.14 versus 4.81±6.96 (p
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fernando2018impairedinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gongora-Rivera, Fernando;Cordero-Perez, Adolfo;Gonzalez-Aquines, Alejandro;Anaya-Escamilla, Antonio;Villarreal-Garza, Eduardo;Espinosa-Ortega, Meztli;Salinas-Carmona, Mario C.;Ortiz-Jimenez, Xochilt;Gongora-Rivera, Fernando;Cordero-Perez, Adolfo;Gonzalez-Aquines, Alejandro;Anaya-Escamilla, Antonio;Villarreal-Garza, Eduardo;Espinosa-Ortega, Meztli;Salinas-Carmona, Mario C.;Ortiz-Jimenez, Xochilt;
Journal international journal of alzheimer’s disease
Year 2018
DOI
10.1155/2018/9328293
URL
https://www.hindawi.com/journals/ijad/2018/9328293/abs/
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