New Hydrazides and Hydrazide-Hydrazones of 2,3-Dihalogen Substituted Propionic Acids: Synthesis and in vitro Antimicrobial Activity Evaluation.

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ID: 104504
2017
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Abstract
The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods ( H-NMR, C-NMR) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines.
Reference Key
popioek2017newchemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Popiołek, Łukasz;Biernasiuk, Anna;
Journal Chemistry & biodiversity
Year 2017
DOI
10.1002/cbdv.201700075
URL
Keywords
Antimicrobial activity hydrazide-hydrazone mic condensation reaction hydrazides

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