New Hydrazides and Hydrazide-Hydrazones of 2,3-Dihalogen Substituted Propionic Acids: Synthesis and in vitro Antimicrobial Activity Evaluation.

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2017
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Abstract
The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods ( H-NMR, C-NMR) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines.
Das Hauptziel dieser Forschungsarbeit war die Synthese, spektroskopische Identifizierung und In-vitro-Evaluierung der antimikrobiellen Aktivität neuer Hydrazide und Hydrazid-Hydrazone von 2,3-dihalogensubstituierten Propionsäuren. Neue Hydrazide wurden durch die Substitutionsreaktion entsprechender Ethylester von 2,3-dihalogensubstituierten Propionsäuren mit Hydrazinhydrat erhalten. Die so erhaltenen Hydrazide wurden anschließend einer Kondensationsreaktion mit verschiedenen Aldehyden unterzogen, was zu neuen Hydrazid-Hydrazon-Derivaten führte. Alle erhaltenen Verbindungen wurden anhand spektroskopischer Methoden (¹H-NMR, ¹³C-NMR) identifiziert und in vitro gemäß den EUCAST- und CLSI-Richtlinien gegen ein Panel von Bakterien- und Pilzstämmen getestet.
Reference Key
popioek2017newchemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Popiołek, Łukasz;Biernasiuk, Anna;
Journal Chemistry & biodiversity
Year 2017
DOI
10.1002/cbdv.201700075
URL
Keywords
Antimicrobial activity hydrazide-hydrazone mic condensation reaction hydrazides

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