Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps

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ID: 104285
2010
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Abstract

Abstract

Background

Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract. Information on adenoma status below the duodenum has previously been restricted due to its inaccessibility in vivo. Capsule Endoscopy (CE) may provide a useful adjunct in screening for polyposis in the small bowel in FAP patients. This study aims to evaluate the effectiveness of CE in the assessment of patients with FAP, compared to other imaging modalities for the detection of small bowel polyps.

Method

20 consecutive patients with previously diagnosed FAP and duodenal polyps, presenting for routine surveillance of polyps at The Royal Melbourne Hospital were recruited. Each fasted patient initially underwent a magnetic resonance image (MRI) of the abdomen, and a barium small bowel follow-through study. Capsule Endoscopy was performed four weeks later on the fasted patient. An upper gastrointestinal side-viewing endoscopy was done one (1) to two (2) weeks after this. Endoscopists and investigators were blinded to results of other investigations and patient history.

Results

Within the stomach, upper gastrointestinal endoscopy found more polyps than other forms of imaging. SBFT and MRI generally performed poorly, identifying fewer polyps than both upper gastrointestinal and capsule endoscopy. CE was the only form of imaging that identified polyps in all segments of the small bowel as well as the only form of imaging able to provide multiple findings outside the stomach/duodenum.

Conclusion

CE provides important information on possible polyp development distal to the duodenum, which may lead to surgical intervention. The place of CE as an adjunct in surveillance of FAP for a specific subset needs consideration and confirmation in replication studies.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12608000616370

Reference Key
paul2010surveillancehereditary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Paul, Tescher;A, Macrae Finlay;Tony, Speer;Damien, Stella;Robert, Gibson;A, Tye-Din Jason;Geeta, Srivatsa;T, Jones Ian;Kaye, Marion;
Journal hereditary cancer in clinical practice
Year 2010
DOI
DOI not found
URL
http://www.hccpjournal.com/content/8/1/3
Keywords
Microbiology Infectious and parasitic diseases Medicine Biotechnology Science surgery Medical emergencies. Critical care. Intensive care. First aid neoplasms. tumors. oncology. including cancer and carcinogens ophthalmology diseases of the respiratory system genetics

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