Size control of the inner ear via hydraulic feedback.

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ID: 103767
2019
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Abstract
Animals make organs of precise size, shape, and symmetry but how developing embryos do this is largely unknown. Here, we combine quantitative imaging, physical theory, and physiological measurement of hydrostatic pressure and fluid transport in zebrafish to study size control of the developing inner ear. We find that fluid accumulation creates hydrostatic pressure in the lumen leading to stress in the epithelium and expansion of the otic vesicle. Pressure, in turn, inhibits fluid transport into the lumen. This negative feedback loop between pressure and transport allows the otic vesicle to change growth rate to control natural or experimentally-induced size variation. Spatiotemporal patterning of contractility modulates pressure-driven strain for regional tissue thinning. Our work connects molecular-driven mechanisms, such as osmotic pressure driven strain and actomyosin tension, to the regulation of tissue morphogenesis via hydraulic feedback to ensure robust control of organ size.This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Reference Key
mosaliganti2019sizeelife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mosaliganti, Kishore R;Swinburne, Ian A;Chan, Chon U;Obholzer, Nikolaus D;Green, Amelia A;Tanksale, Shreyas;Mahadevan, L;Megason, Sean G;
Journal eLife
Year 2019
DOI
10.7554/eLife.39596
URL
Keywords
systems biology growth developmental biology zebrafish pressure computational biology inner ear size control systems modeling transepithelial flow

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