Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry.

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ID: 103676
2020
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Abstract
The data supplied in this work are related to the research article entitled "Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry" (Phung et al., 2019). This data article describes a powerful analytical platform using native weak cation exchange chromatography coupled to a high-resolution mass spectrometer, charge variant mass spectrometry (CV-MS), to characterize bispecific and mispaired antibody species. Elution order is investigated through analytical methods and molecular modeling in an effort to understand the intrinsic charge, size and shape differences of these molecules.
Reference Key
phung2020datadata Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Phung, Wilson;Han, Guanghui;Polderdijk, Stéphanie G I;Dillon, Michael;Shatz, Whitney;Liu, Peter;Wei, Bingchuan;Suresh, Pawankumar;Fischer, David;Spiess, Christoph;Bailey, Aaron;Carter, Paul J;Lill, Jennie R;Sandoval, Wendy;
Journal Data in brief
Year 2020
DOI
10.1016/j.dib.2020.105435
URL
Keywords
single cell native mass spectrometry ion exchange chromatography bispecific antibody charge variant mass spectrometry cognate pairs molecular model weak cation exchange

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