Nybomycin-producing Streptomyces isolated from carpenter ant Camponotus vagus.

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ID: 1033
2019
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Abstract
A novel strain of Actinomycetes was isolated from the body of an ant (Camponotus vagus Scopoli) and its genetic and morphological properties were characterized. The 16S rDNA gene sequence analysis of the isolate revealed its high phylogenetic relationship with type strains of Streptomyces violaceochromogenes NBRC 13100. As a result of antimicrobial activity assessment, it was found that the fermentation broth of the isolated strain both inhibited the growth and induced the SOS response in E. coli BW25113 ΔtolC strain cells. Using bioassay-guided fractionation, mass spectrometric and NMR analyses we identified the active compound to be nybomycin, a previously described antibiotic. Here we report for the first time Streptomyces producer of nybomycin in association with carpenter ants and demonstrate cytotoxic activity of nybomycin against human cell lines.
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zakalyukina2019nybomycin-producing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zakalyukina, Yuliya V;Birykov, Mikhail V;Lukianov, Dmitrii A;Shiriaev, Dmitrii I;Komarova, Ekaterina S;Skvortsov, Dmitry A;Kostyukevich, Yury;Tashlitsky, Vadim N;Polshakov, Vladimir I;Nikolaev, Eugene;Sergiev, Petr V;Osterman, Ilya A;
Journal biochimie
Year 2019
DOI
S0300-9084(19)30049-5
URL
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