Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.

Clicks: 482
ID: 103216
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #3 of 7 articles by views in cell host & microbe

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.
Reference Key
kim2020infectioncell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Young-Il;Kim, Seong-Gyu;Kim, Se-Mi;Kim, Eun-Ha;Park, Su-Jin;Yu, Kwang-Min;Chang, Jae-Hyung;Kim, Eun Ji;Lee, Seunghun;Casel, Mark Anthony B;Um, Jihye;Song, Min-Suk;Jeong, Hye Won;Lai, Van Dam;Kim, Yeonjae;Chin, Bum Sik;Park, Jun-Sun;Chung, Ki-Hyun;Foo, Suan-Sin;Poo, Haryoung;Mo, In-Pil;Lee, Ok-Jun;Webby, Richard J;Jung, Jae U;Choi, Young Ki;
Journal cell host & microbe
Year 2020
DOI
S1931-3128(20)30187-6
URL
Keywords
transmission covid-19 sars-cov-2 2019-ncov severe acute respiratory syndrome coronavirus 2 2019-novel coronavirus ferrets novel coronavirus disease virus shedding

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.