Phenotypic profiling of mGlu knockout mice reveals new implications for neurodevelopmental disorders.

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ID: 103024
2020
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Abstract
Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, GRM7, encodes the metabotropic glutamate receptor 7 (mGlu ), a G protein-coupled receptor that regulates pre-synaptic neurotransmitter release. Mutations and polymorphisms in GRM7 have been associated with neurodevelopmental disorders in clinical populations; however, limited pre-clinical studies have evaluated mGlu in the context of this specific disease class. Here, we demonstrate that the absence of mGlu in mice is sufficient to alter phenotypes within the domains of social behavior, associative learning, motor function, epilepsy and sleep. Moreover, Grm7 knockout mice exhibit an attenuated response to amphetamine. These findings provide rationale for further investigation of mGlu as a potential therapeutic target for neurodevelopmental disorders such as idiopathic autism, attention deficit hyperactivity disorder, and Rett syndrome.
Reference Key
fisher2020phenotypicgenes Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fisher, Nicole M;Gould, Robert W;Gogliotti, Rocco G;McDonald, Annalise J;Badivuku, Hana;Chennareddy, Susmita;Buch, Aditi B;Moore, Annah M;Jenkins, Matthew T;Robb, W Hudson;Lindsley, Craig W;Jones, Carrie K;Conn, P Jeffrey;Niswender, Colleen M;
Journal genes, brain, and behavior
Year 2020
DOI
10.1111/gbb.12654
URL
Keywords
EEG epilepsy autism seizures adhd attention deficit hyperactivity disorder asd rett syndrome grm7 mglu7

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