COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

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ID: 102954
2020
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Abstract
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak. Keywords: Coronaviruses, COVID-19, Origin, Outbreak, Spread
Reference Key
shereen2020covid19journal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shereen, M.A.
Journal journal of advanced research
Year 2020
DOI
10.1016/j.jare.2020.03.005
URL
http://www.sciencedirect.com/science/article/pii/S2090123220300540
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