Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study.

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ID: 102267
2020
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Abstract
Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF). The tolerability, rapid acquisition and lower radiation and cost compared with CT imaging may make DCR a useful adjunct to current standards of care.This is an observational, non-controlled, non-randomised, single-centre, prospective study. This study is conducted at the Liverpool Heart and Chest Hospital (LHCH) adult CF unit. Participants are adults with CF. This study reviews DCR taken during routine CF Annual Review (n=150), validates DCR-derived lung volumes against whole body plethysmography (n=20) and examines DCR at the start and end of pulmonary exacerbations of CF (n=20). The primary objectives of this study are to examine if DCR provides lung function information that correlates with PFT, and lung volumes that correlate whole body plethysmography.This study has received the following approvals: HRA REC (11 December 2019) and LHCH R&I (11 October 2019). Results are made available to people with CF, the funders and other researchers. Processed, anonymised data are available from the research team on request.ISRCTN 64994816.
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fitzmaurice2020utilitybmj Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors FitzMaurice, Thomas Simon;McNamara, Paul Stephen;Nazareth, Dilip;McCann, Caroline;Bedi, Ram;Shaw, Matthew;Walshaw, Martin;
Journal bmj open respiratory research
Year 2020
DOI
e000569
URL
Keywords
respiratory infection cystic fibrosis lung physiology respiratory muscles

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