[Treatment of Hepatitis C: State of the Art 2018].

Clicks: 320
ID: 102145
2018
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #8 of 16 articles by views in deutsche medizinische wochenschrift (1946)

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Aim of antiviral therapy on an individual patient level is a sustained virologic response, on a population level the elimination of the hepatitis C virus (HCV). The latter is an aim also defined by the WHO.Specific inhibitors of the RNA-dependent RNA-polymerase, the NS3/4A protease, and the NS5A protein as well as ribavirin are available for antiviral therapy of HCV. Typically, two direct antiviral agents are combined, the treatment duration for the majority of patients is between 8 and 12 weeks. Potential drug-drug interactions with patients' basic medications must be assessed.Two pangenotypic regimens are available: sofosbuvir/velpatasvir and glecaprevir/pibrentasvir. In the individual decision between regimens hepatic and renal function as well as drug-drug interactions must be considered. The sustained virologic response rates are above 95 %, safety and tolerability of the treatment regimens are excellent.In patients with decompensated cirrhosis treatment with protease inhibitors is contraindicated. Sofosbuvir is not approved in patients with severe renal insufficiency. Patients who failed an interferon-free therapy should be retreated with sofosbuvir/velpatasvir/voxilaprevir.
Reference Key
zeuzem2018treatmentdeutsche Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zeuzem, Stefan;
Journal deutsche medizinische wochenschrift (1946)
Year 2018
DOI
10.1055/a-0591-5916
URL
Keywords
evidence child abuse wirksamkeit kindesmisshandlung schutzfaktoren data triangulation methodische triangulation protection factors subjective evaluation subjektive bewertungen

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.