Serum Metabolites in Hand-Arm Vibration Exposed Workers.

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ID: 102079
2020
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Abstract
To investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.The study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with GC-TOFMS. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.Twenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from participants without VWF, both before and after vibration exposure.Metabolites that differed between the groups were identified both before and after exposure. Some of these metabolites might be indicators of health effects from exposure to vibrations. This is the first time that a metabolomic approach has been used in workers exposed to vibrations.
Reference Key
vihlborg2020serumjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Vihlborg, Per;Graff, Pål;Hagenbjörk, Annika;Hadrévi, Jenny;Bryngelsson, Ing-Liss;Eriksson, Kåre;
Journal journal of occupational and environmental medicine
Year 2020
DOI
10.1097/JOM.0000000000001864
URL
Keywords
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