Sesquiterpenoids from the roots of Daphne genkwa Siebold et Zucc. With potential anti-inflammatory activity.

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ID: 101770
2020
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Abstract
Six undescribed sesquiterpenoids, including three acorane-type sesquiterpenoids (daphneaines A-C), three guaiane-type sesquiterpenoids (daphneaines E-G) and three known analogues were isolated from the roots of Daphne genkwa Siebold et Zucc. Their gross structures were elucidated by comprehensive spectroscopic analyses. The relative configurations of daphneaines A-C were determined by NOESY experiments. In addition, the relative configuration of daphneaine G was elucidated by performing a quantum chemical calculation of the NMR chemical shifts coupled with an advanced statistical procedure DP4+. The comparison of experimental and calculated electronic circular dichroism (ECD) data led to the establishment of the absolute configurations of daphneaines A-G. All isolates were tested for their inhibitory activity towards the LPS-induced NO production in RAW 264.7 macrophages, and daphneaine F showed inhibitory effect on NO production with an IC value of 35.68 ± 3.18 μM.
Reference Key
guo2020sesquiterpenoidsphytochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guo, Rui;Ren, Qiang;Tang, Ya-Xin;Zhao, Feng;Lin, Bin;Huang, Xiao-Xiao;Song, Shao-Jiang;
Journal Phytochemistry
Year 2020
DOI
S0031-9422(19)31205-1
URL
Keywords
anti-inflammatory activity sesquiterpenoid thymelaeaceae daphne genkwa siebold et zucc.

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