PGRP-SA regulates Antimicrobial Response to Bacteria and Fungi in the Fat Body and Gut of .

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ID: 101436
2020
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Abstract
Antimicrobial immune response is mediated by a signal-transducing sensor, peptidoglycan recognition protein-SA (PGRP-SA), that can recognize non-self molecules. Although several studies have focused on the involvement of PGRP-SA in antimicrobial peptide (AMP) expression in response to infections, studies on its role in are lacking. Here, we present a functional analysis of PGRP-SA (PGRP-SA). In the absence of microbes, was highly expressed in the late-larval fat body, followed by hemocytes, and gut. Interestingly, following , , and infections, the mRNA level of was significantly upregulated in both the fat body and gut. silencing had a significant effect on the mortality rates for all the microbes tested. Moreover, is required for regulating the expression of eight AMP genes namely , -, and ; and ; ; and and in the fat body in response to and infections. is essential for the transcription of , ; ; , ; and , , and in the gut upon and infections. However, does not regulate AMP expression in the hemocytes. Additionally, Dorsal isoform X2, a downstream Toll transcription factor, was downregulated in -silenced larval fat body following and challenges, and in the gut following and challenges.
Reference Key
keshavarz2020pgrpsainternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Keshavarz, Maryam;Jo, Yong Hun;Edosa, Tariku Tesfaye;Bae, Young Min;Han, Yeon Soo;
Journal International journal of molecular sciences
Year 2020
DOI
E2113
URL
Keywords
antimicrobial peptide expression pattern tenebrio molitor nuclear factor κb tmpgrp-sa

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