Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substituted p-QMs with α-nitroketones.
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2020
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Abstract
A novel organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substituted p-QMs with α-nitroketones is described. A variety of novel chiral 2-(1-(4-hydroxyphenyl)ethyl)phenols are constructed for the first time with high yields (up to 92%) and excellent enantioselectivities (up to >99% ee) under mild reaction conditions. A gram-scale experiment of this process is also presented.
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zhou2020organocatalyticorganic
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| Authors | Zhou, Jing;Bai, Li-Juan;Liang, Guo-Juan;Xu, Qi-Gui;Zhou, Li-Ping;Zhou, Hui; |
| Journal | Organic & biomolecular chemistry |
| Year | 2020 |
| DOI |
10.1039/d0ob00397b
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