Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of in the Americas.

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ID: 100863
2019
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Abstract
Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in to understand the parasites' successful establishment on the continent.
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boit2019transatlanticgenes Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Boité, Mariana C;Späth, Gerald F;Bussotti, Giovanni;Porrozzi, Renato;Morgado, Fernanda N;Llewellyn, Martin;Schwabl, Philipp;Cupolillo, Elisa;
Journal genes
Year 2019
DOI
E4
URL
Keywords
americas leishmania visceral leishmaniasis fitness gain genome instability

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