Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China.

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ID: 100841
2020
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Abstract
Human respiratory syncytial virus (RSV) is one of the major viruses of acute respiratory tract disease among infants and young children. We performed molecular epidemiology analysis of RSV among inpatient children in Guangzhou, China. Phylogenetic and Bayesian analysis showed that genotype ON1 was the only subgroup A virus in this study. Interestingly, the majority of Guangzhou ON1 strains formed a well-supported cluster, and these strains shared a novel set of five amino acid substitutions that never illustrated before. Furthermore, the degree of disease severity was assessed using a severity scoring system. The patients carrying the novel RSV A strain were associated with milder respiratory symptoms compared to other RSV A positives. In conclusion, a specific set of five amino acid substitutions was found in China and further analysis showed that disease severity was associated with these alterations. These findings will provide valuable information for the pathogenic mechanism and vaccine development of RSV.
Reference Key
li2020diseasevirus Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Wanwei;Wang, Yanlan;Yu, Bo;Tan, Qiqi;Zhou, Jijian;Hu, Jingjing;Wu, Yuanbin;Wang, Bo;Li, Hongjian;
Journal virus research
Year 2020
DOI
S0168-1702(19)30741-5
URL
Keywords
mutations disease severity g protein gene human respiratory syncytial virus on1 genotype

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