Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila.

Clicks: 367
ID: 100836
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #6 of 9 articles by views in cell metabolism

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that high sugar induces dehydration in adult Drosophila, and water supplementation fully rescues their lifespan. Conversely, the metabolic defects are water-independent, showing uncoupling between sugar-induced obesity and insulin resistance with reduced survival in vivo. High-sugar diets promote accumulation of uric acid, an end-product of purine catabolism, and the formation of renal stones, a process aggravated by dehydration and physiological acidification. Importantly, regulating uric acid production impacts on lifespan in a water-dependent manner. Furthermore, metabolomics analysis in a human cohort reveals that dietary sugar intake strongly predicts circulating purine levels. Our model explains the pathophysiology of high-sugar diets independently of obesity and insulin resistance and highlights purine metabolism as a pro-longevity target.
Reference Key
van-dam2020sugarinducedcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors van Dam, Esther;van Leeuwen, Lucie A G;Dos Santos, Eliano;James, Joel;Best, Lena;Lennicke, Claudia;Vincent, Alec J;Marinos, Georgios;Foley, Andrea;Buricova, Marcela;Mokochinski, Joao B;Kramer, Holger B;Lieb, Wolfgang;Laudes, Matthias;Franke, Andre;Kaleta, Christoph;Cochemé, Helena M;
Journal cell metabolism
Year 2020
DOI
S1550-4131(20)30075-9
URL
Keywords
Diabetes obesity aging uric acid drosophila high-sugar diet purine catabolism water imbalance

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.