Cell-Membrane-Mimicking Nanodecoys against Infectious Diseases.

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ID: 100834
2020
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Abstract
Infectious diseases are a leading cause of mortality worldwide, with viruses and bacteria in particular having enormous impacts on global healthcare. One major challenge in combatting such diseases is a lack of effective drugs or specific treatments. In addition, drug resistance to currently available therapeutics and adverse effects caused by long-term overuse are both serious public health issues. A promising treatment strategy is to employ cell-membrane mimics as decoys to trap and to detain the pathogens. In this Perspective, we briefly review the infection mechanisms adopted by different pathogens at the cellular membrane interface and highlight the applications of cell-membrane-mimicking nanodecoys for systemic protection against infectious diseases. We also discuss the implication of nanodecoy-pathogen complexes in the development of vaccines. We anticipate this Perspective will provide new insights on design and development of advanced materials against emerging infectious diseases.
Reference Key
rao2020cellmembranemimickingacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rao, Lang;Tian, Rui;Chen, Xiaoyuan;
Journal acs nano
Year 2020
DOI
10.1021/acsnano.0c01665
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