Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus.

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ID: 100815
2019
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Abstract
Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC of 52 ± 8 μg mL. CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC lowered to 5.2 ± 0.7 μg mL. The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.
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oczechin2019functionalacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Łoczechin, Aleksandra;Séron, Karin;Barras, Alexandre;Giovanelli, Emerson;Belouzard, Sandrine;Chen, Yen-Ting;Metzler-Nolte, Nils;Boukherroub, Rabah;Dubuisson, Jean;Szunerits, Sabine;
Journal ACS applied materials & interfaces
Year 2019
DOI
10.1021/acsami.9b15032
URL
Keywords
antiviral therapy boronic acid carbon quantum dots (cqds) human coronavirus (hcov) multivalent interactions

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