Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development

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ID: 100774
2018
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Abstract
Immunogenic apoptosis, or more appropriately called immunogenic cell death (ICD), is a recently described form of apoptosis induced by a specific set of chemotherapeutic drugs or by physical therapeutic modalities, such as ionizing irradiation and photodynamic therapy. The peculiar characteristic of ICD is the ability to favor recognition and elimination of dying tumor cells by phagocytes in association with the release of pro-inflammatory molecules (such as cytokines and high-mobility group box-1). While in vitro and animal models pointed to ICD as one of the molecular mechanisms mediating the clinical efficacy of some anticancer agents, it is hard to clearly demonstrate its contribution in cancer patients. Clinical evidence suggests that the induction of ICD alone is possibly not sufficient to fully subvert the immunosuppressive tumor microenvironment. However, interesting results from recent studies contemplate the exploitation of ICD for improving the immunogenicity of cancer cells to use them as an antigen cargo in the development of dendritic cell (DC) vaccines. Herein, we discuss the effects of danger signals expressed or released by cancer cells undergoing ICD on the maturation and activation of immature and mature DC, highlighting the potential added value of ICD in adoptive immunotherapy protocols.
Reference Key
montico2018immunogenicinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Montico, Barbara;Nigro, Annunziata;Casolaro, Vincenzo;Col, Jessica Dal;
Journal International journal of molecular sciences
Year 2018
DOI
DOI not found
URL
http://www.mdpi.com/1422-0067/19/2/594
Keywords
chemistry microscopy Biology (General) Medicine (General) Medicine Engineering (General). Civil engineering (General) Technology Electrical engineering. Electronics. Nuclear engineering Descriptive and experimental mechanics Science Immunologic diseases. Allergy neoplasms. tumors. oncology. including cancer and carcinogens diseases of the digestive system. gastroenterology

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