The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus.

Clicks: 273
ID: 100765
2020
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Abstract
Oncolytic viruses, including live attenuated measles virus (MV) vaccine strains, have recently been shown as promising therapeutic agents against human malignancies. In this study, the oncolytic potential of the attenuated vaccine strain Leningrad-16 (L-16) of MV was evaluated in a panel of human metastatic melanoma cell lines. The L-16 measles virus was shown to replicate within melanoma cells mediating direct cell killing of tumor cells, although all melanoma cell lines varied in regard to their ability to respond to L-16 MV infection, as revealed by the different pattern of the Interferon Stimulated Gene expression, cytokine release and mechanisms of cell death. Furthermore, the statistically significant L-16 measles virus related tumor growth inhibition was demonstrated in a melanoma xenograft model. Therefore, L-16 MV represents an appealing oncolytic platform for target delivery of therapeutic genes along with other attenuated measles virus strains.
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ammour2020theviruses Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ammour, Yulia;Ryabaya, Oxana;Shchetinina, Yulia;Prokofeva, Elena;Gavrilova, Marina;Khochenkov, Dmitry;Vorobyev, Denis;Faizuloev, Evgeny;Shohin, Igor;Zverev, Vitaly V;Svitich, Oxana;Nasedkina, Tatiana;
Journal Viruses
Year 2020
DOI
E173
URL
Keywords
cancer immunotherapy oncolytic viruses measles virus

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