A Review of Nanotechnology for Targeted Anti-schistosomal Therapy.

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ID: 100760
2020
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Ranked #11 of 41 articles by views in Frontiers in bioengineering and biotechnology

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Abstract
Schistosomiasis is one of the major parasitic diseases and second most prevalent among the group of neglected diseases. The prevalence of schistosomiasis may be due to environmental and socio-economic factors, as well as the unavailability of vaccines for schistosomiasis. To date, current treatment; mainly the drug praziquantel (PZQ), has not been effective in treating the early forms of schistosome species. The development of drug resistance has been documented in several regions globally, due to the overuse of PZQ, rate of parasitic mutation, poor treatment compliance, co-infection with different strains of schistosomes and the overall parasite load. Hence, exploring the schistosome tegument may be a potential focus for the design and development of targeted anti-schistosomal therapy, with higher bioavailability as molecular targets using nanotechnology. This review aims to provide a concise incursion on the use of various advance approaches to achieve targeted anti-schistosomal therapy, mainly through the use of nano-enabled drug delivery systems. It also assimilates the molecular structure and function of the schistosome tegument and highlights the potential molecular targets found on the tegument, for effective specific interaction with receptors for more efficacious anti-schistosomal therapy.
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adekiya2020afrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Adekiya, Tayo Alex;Kondiah, Pierre P D;Choonara, Yahya E;Kumar, Pradeep;Pillay, Viness;
Journal Frontiers in bioengineering and biotechnology
Year 2020
DOI
10.3389/fbioe.2020.00032
URL
Keywords
nanoparticles drug delivery antibody schistosomiasis aptamers targeted agents molecular receptors

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