Influence of cannabinoids upon nerve-evoked skeletal muscle contraction.

Clicks: 365
ID: 100636
2020
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Abstract
Endocannabinoids play important roles in regulating CNS synaptic function and peripheral metabolism, but cannabinoids can also act acutely to modulate contraction strength in skeletal muscle. Nerve terminals and the skeletal muscle sarcolemma express components of the cannabinoid signaling system. Endocannabinoids, N-arachidonylethanolamine (anandamide, AEA) and 2-arachidonoyl-glycerol (2-AG), are produced by skeletal muscle. They may be involved in the acute regulation of neuromuscular transmission, by adjusting the parameters for quantal acetylcholine release from the motor nerve terminal. Downstream of neuromuscular transmission, cannabinoids may also act to limit the efficiency of excitation-contraction coupling. Improved understanding of the distinct signaling actions of particular cannabinoid compounds and their receptor/transduction systems will help advance our understanding of the role of endocannabinoids in skeletal muscle physiology. Cannabinoids might also offer the potential to develop new pharmacotherapeutics to treat neuromuscular disorders that affect muscle strength.
Reference Key
ge2020influenceneuroscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ge, Dengyun;Odierna, G Lorenzo;Phillips, William D;
Journal neuroscience letters
Year 2020
DOI
S0304-3940(20)30170-1
URL
Keywords
endocannabinoids neuromuscular disease myasthenia gravis spasticity anandamide dihydropyridine receptor l-type calcium channels neuromuscular junction

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