Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis.

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ID: 100384
2019
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Abstract
We sought to identify patients with amyotrophic lateral sclerosis (ALS) who displayed suspected peripheral nervous system (PNS) inflammation to compare them to those with suspected PNS degeneration.We measured sonographic median and ulnar nerve cross-sectional area (CSA) and cerebrospinal fluid albumin/serum albumin ratio (Q ) in patients with ALS to classify them as having suspected PNS degeneration (small CSA/low Q ) or inflammation (larger CSA/high Q ).Fifty-seven percent of patients had suspected PNS degeneration, 21% had suspected PNS inflammation, and 21% displayed suspected "normal PNS state." Suspected PNS degeneration was related to classic ALS, shorter disease duration, and a smaller hypoechoic nerve area. Suspected PNS inflammation was associated with men, longer disease duration, and a larger hypoechoic nerve area and was the dominant finding in superoxide dismutase 1 mutation carriers.Our simple approach might aid in the in vivo differentiation of supposed ALS subtypes, those with suspected PNS degeneration vs. inflammation, for stratification in clinical trials. Muscle Nerve 59:567-567, 2019.
Reference Key
schreiber2019towardmuscle Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Schreiber, Stefanie;Schreiber, Frank;Garz, Cornelia;Debska-Vielhaber, Grazyna;Assmann, Anne;Perosa, Valentina;Petri, Susanne;Dengler, Reinhard;Nestor, Peter;Vielhaber, Stefan;
Journal muscle & nerve
Year 2019
DOI
10.1002/mus.26444
URL
Keywords
ultrasound peripheral nervous system peripheral neuropathy cerebrospinal fluid als peripheral nervous system inflammation

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