Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

Clicks: 331
ID: 10036
2019
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Abstract
We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice. In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. The HemoHIM prevented the cisplatin-induced loss of body and organ weight. In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group. The HemoHIM group also showed a significantly higher expression of Th1-mediated cytokines (interferon gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α)) and inhibited the production of Th2-mediated cytokine interleukin-4 (IL-4) compared to cisplatin control group. These findings indicate that HemoHIM enhances immune activity by modulating immune cell activity and cytokine secretion in immune-suppressed mice.
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seulki2019preventiveevidencebased Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Seul-Ki;Kwon, Da-Ae;Lee, Hak Sung;Kim, Hyun Kyu;Kim, Won-Ki;Kim, Seul-Ki;Kwon, Da-Ae;Lee, Hak Sung;Kim, Hyun Kyu;Kim, Won-Ki;
Journal evidence-based complementary and alternative medicine
Year 2019
DOI
10.1155/2019/3494806
URL
https://www.hindawi.com/journals/ecam/2019/3494806/abs/
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