Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates.

Clicks: 459
ID: 100194
2018
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Abstract
The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff's bases ( and ) were designed and synthesized, and their respective chemical structures were deduced using various spectral tools (IR, H NMR, C NMR, and MS). The compounds were synthesized via Schiff's condensation reaction and their anti-inflammatory activity was investigated applying the Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that all compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity was supported via virtual screening using molecular docking study. Interestingly compound showed the highest in vivo activity (61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765) and the virtual screening docking score (-12.142).
Reference Key
ibrahim2018synthesisinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ibrahim, Musab Mohamed;Elsaman, Tilal;Al-Nour, Mosab Yahya;
Journal international journal of medicinal chemistry
Year 2018
DOI
10.1155/2018/9139786
URL
Keywords
Anti-cancer activity Cytotoxicity isatin sulfonamides egfr tyrosine kinase schiff's bases hydrazones morpholin

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