Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: Synthesis, SAR and molecular docking.

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ID: 100183
2019
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Abstract
A novel series of amino acids conjugated quinazolinone-Schiff's bases were synthesized and screened for their in vitro anticancer activity and validated by molecular docking and DNA binding studies. In the present investigations, compounds 32, 33, 34, 41, 42 and 43 showed most potent anticancer activity against tested cancer cell lines and DNA binding study using methyl green comparing to doxorubicin and ethidium bromide as a positive control respectively. The structure-activity relationship (SAR) revealed that the tryptophan and phenylalanine derived electron donating groups (OH and OCH) favored DNA binding studies and anticancer activity whereas; electron withdrawing groups (Cl, NO, and F) showed least anticancer activity. The molecular docking study, binding interactions of the most active compounds 33, 34, 42 and 43 stacked with A-T rich regions of the DNA minor groove by surface binding interactions were confirmed.
Reference Key
rakesh2019anticancerbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rakesh, K P;Kumara, H K;Manukumar, H M;Channe Gowda, D;
Journal Bioorganic chemistry
Year 2019
DOI
S0045-2068(19)30088-4
URL
Keywords
anticancer docking study amino acids dna binding quinazolinone

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