Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage.

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ID: 100097
2017
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Abstract
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has led to the development of potential DEHP substitutes. Here, we compared the red blood cell preservation ability of two types of non-DEHP blood containers with safe alternative plasticizers to that of DEHP blood containers. Red cell concentrates in mannitol-adenine-phosphate solution (MAP/RCC) were stored for 6 weeks in PVC blood bags containing DEHP, di-isononyl-cyclohexane-1,2-dicarboxylate (DINCH) and di (2-ethylhexyl) 4-cyclohexene-1,2-dicarboxylate (DOTH), or 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH) and DOTH. There was no significant difference in the total amount of plasticizer eluted into MAP/RCC (till 3 weeks from the beginning of the experiment), hemolysis of MAP/RCC, and osmotic fragility of MAP/RCC between the non-DEHP blood containers and DEHP blood containers. Hematological and blood chemical indices of MAP/RCC in all containers were nearly the same. Thus, DOTH/DINCH and DOTH/DL9TH blood containers demonstrate the same quality of MAP/RCC storing as the DEHP blood containers. Since DOTH, DINCH, and DL9TH were reported to be safe, DOTH/DINCH and DOTH/DL9TH blood containers are promising candidate substitutes for DEHP blood containers.
Reference Key
morishita2017pilotplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Morishita, Yuki;Nomura, Yusuke;Fukui, Chie;Kawakami, Tsuyoshi;Ikeda, Toshiyuki;Mukai, Tomokazu;Yuba, Toshiyasu;Inamura, Ken-Ichi;Yamaoka, Hisatoki;Miyazaki, Ken-Ichi;Okazaki, Hitoshi;Haishima, Yuji;
Journal PloS one
Year 2017
DOI
10.1371/journal.pone.0185737
URL
http://europepmc.org/articles/PMC5619825?pdf=render
Keywords
infection complication healthcare utilization spinal cord stimulation

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