Cobalt-Catalyzed Intermolecular Markovnikov Hydroamination of Nonactivated Olefins: -Selective Alkylation of Benzotriazole.
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2020
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Abstract
Cobalt-catalyzed Markovnikov-selective hydroamination of nonactivated olefins was developed. Hydrogen atom transfer from a catalytically generated cobalt(III)-hydride complex to the olefins proceeded regioselectively, and the nucleophilic addition of benzotriazoles occurred selectively at their -positions. The synthetic utility of the obtained -alkylated benzotriazoles as stable amine protecting groups under various reaction conditions was demonstrated, and the products were also transformed into primary amines by zinc-mediated reduction.| Reference Key |
yahata2020cobaltcatalyzedorganic
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| Authors | Yahata, Kenzo;Kaneko, Yuki;Akai, Shuji; |
| Journal | Organic letters |
| Year | 2020 |
| DOI | 10.1021/acs.orglett.9b04375 |
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