Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani

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ID: 273285
1999
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Abstract
To determine the relative contributions of respiratory burst-derived reactive oxygen intermediates (ROI) versus reactive nitrogen intermediates (RNI) to macrophage-mediated intracellular host defense, mice genetically deficient in these mechanisms were challenged with Leishmania donovani, a protozoa ā€¦
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Authors Murray HW;Nathan CF;;
Journal The Journal of experimental medicine
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9989990
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't Comparative Study P.H.S. Knockout genetic predisposition to disease chronic / complications membrane glycoproteins / genetics Chronic / genetics granulomatous disease membrane glycoproteins / physiology* leishmania donovani / immunology* leishmaniasis visceral / immunology* h w murray liver / parasitology nitric oxide synthase / deficiency nitric oxide synthase / genetics nitric oxide synthase type ii chronic / immunology* nadph oxidases / genetics nadph oxidase 2 pmid:9989990 pmc2192937 doi:10.1084/jem.189.4.741 c f nathan granuloma / etiology granuloma / immunology granuloma / parasitology granuloma / pathology visceral / complications macrophage activation / physiology* macrophages / parasitology macrophages / physiology* membrane glycoproteins / deficiency nadph oxidases / deficiency nadph oxidases / physiology* nitric oxide / immunology* nitric oxide synthase / physiology* reactive oxygen species / immunology*

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