Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia

Clicks: 184
ID: 269645
2019
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Background Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both normal healthy cells and leukemic blasts from cell death. We assessed whether Leucovorin is able to restore red blood cell folate levels after MTX. Methods We prospectively determined erythrocyte folate levels (5-methyltetrahydrofolate (THF) and non-methyl THF) and serum folate levels in 67 children with ALL before start (T0) and after stop (T1) of HD-MTX and Leucovorin courses. Results Erythrocyte folate levels increased between T0 and T1 (mean ± SD: 416.7 ± 145.5 nmol/L and 641.2 ± 196.3 nmol/L respectively, p
Reference Key
oosterom2019ploschanges Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Natanja Oosterom;Robert de Jonge;Desiree E. C. Smith;Rob Pieters;Wim J. E. Tissing;Marta Fiocco;Bertrand D. van Zelst;Marry M. van den Heuvel-Eibrink;Sandra G. Heil;
Journal PloS one
Year 2019
DOI 10.1371/journal.pone.0221591
URL
https://dx.doi.org/10.1371/journal.pone.0221591
Keywords
Pediatrics oncology cancer treatment methotrexate red blood cells acute lymphoblastic leukemia Blood plasma cobalamins

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.