Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

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ID: 269427
2011
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Abstract
Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice ( …
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Authors Könner AC;Hess S;Tovar S;Mesaros A;Sánchez-Lasheras C;Evers N;Verhagen LA;Brönneke HS;Kleinridders A;Hampel B;Kloppenburg P;Brüning JC;;
Journal cell metabolism
Year 2011
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21641553
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice adiposity gene expression animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Insulin / pharmacology* Receptors Knockout inbred icr neurons / drug effects signal transduction motor activity / drug effects insulin / metabolism neurons / metabolism* motor activity / genetics receptor insulin / genetics calorimetry indirect action potentials pmid:21641553 doi:10.1016/j.cmet.2011.03.021 a christine könner simon hess jens c brüning catecholamines / metabolism cocaine / pharmacology eating / genetics energy metabolism / drug effects* homeostasis / drug effects* hyperinsulinism / genetics mesencephalon / cytology mesencephalon / drug effects dopamine d2 / genetics dopamine d2 / metabolism tyrosine 3-monooxygenase / genetics tyrosine 3-monooxygenase / metabolism

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