Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling

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ID: 269147
2013
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Abstract
Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organiza …
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Authors Romero D;Kawano Y;Bengoa N;Walker MM;Maltry N;Niehrs C;Waxman J;Kypta R;;
Journal journal of cell science
Year 2013
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/23444370##publication-types
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male cell line Knockout immunohistochemistry blotting western morphogenesis / genetics adaptor proteins signal transducing smad proteins / genetics transforming growth factor beta / genetics transforming growth factor beta / metabolism* pmid:23444370 doi:10.1242/jcs.119388 Diana Romero Yoshiaki Kawano Robert Kypta Intercellular Signaling Peptides and Proteins / genetics Intercellular Signaling Peptides and Proteins / metabolism* Morphogenesis / physiology* Prostate / cytology* Prostate / metabolism* Smad Proteins / metabolism*

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