Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

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ID: 268382
1999
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Abstract
The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood. We recently identified the ink4a-ARF tumor suppressor locus as a critical downstream target of the Polycomb-group transcriptional repressor Bmi-1. Others have shown th ā€¦
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Authors Jacobs JJ;Scheijen B;Voncken JW;Kieboom K;Berns A;van Lohuizen M;;
Journal genes & development
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10541554
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression animals pubmed abstract nih national institutes of health national library of medicine female male Cells Cultured Genes Knockout Nuclear Proteins / genetics* lymphoma proteins / genetics* apoptosis / genetics* cell transformation proto-oncogene proteins / genetics* down-regulation heterozygote myc* Tumor Suppressor Protein p14ARF mutant strains repressor proteins* neoplastic / genetics pmid:10541554 pmc317101 doi:10.1101/gad.13.20.2678 j j jacobs b scheijen m van lohuizen cocarcinogenesis bcl-2 p16* b-cell / etiology* b-cell / genetics* b-cell / pathology polycomb repressive complex 1

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