the association of retinopathy and plasma glucose and hba1c: a validation of diabetes diagnostic criteria in a chinese population
Clicks: 365
ID: 257547
2016
Aims. This study aimed to evaluate the associations of diabetic retinopathy (DR) with fasting plasma glucose (FPG), 2-hour postload plasma glucose (2hPG), and glycated hemoglobin A1c (HbA1c) in a Chinese population. Materials and Methods. A total of 3124 participants, identified from a population-based survey in Pinggu district, were examined by retinal photography (45°). DR was classified according to the Early Treatment Diabetic Retinopathy Study scale. FPG, 2hPG, and HbA1c were tested and categorized by deciles, with the prevalence of DR calculated in each decile. Results. The prevalence of DR increased sharply in the 10th deciles, when FPG exceeded 7.03 mmol/L and HbA1c exceeded 6.4%. Analysis of the receiver operating characteristic curves showed that the optimal cutoffs for detecting DR were 6.52 mmol/L and 5.9% for FPG and HbA1c, respectively. The World Health Organization (WHO) criteria for diagnosing diabetes showed high specificity (90.5–99.5%) and low sensitivity (35.3–65.0%). Further, 6 individuals with retinopathy had normal plasma glucose; however, their characteristics did not differ from those without retinopathy. Conclusions. Thresholds of FPG and HbA1c for detecting DR were observed, and the WHO criteria of diagnosing diabetes were shown to have high specificity and low sensitivity in this population.
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| Authors | ;Rui Zhang;Yufeng Li;Simin Zhang;Xiaoling Cai;Xianghai Zhou;Linong Ji |
| Journal | applied computer science |
| Year | 2016 |
| DOI | 10.1155/2016/4034129 |
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| Keywords |
pharmacokinetics
anger
diseases of the musculoskeletal system
contraception
deformation
damage
inflammatory factor
rat plasma
eigenvalues
sichuan basin
pharmacology
clinical endocrinology
diseases of the endocrine glands
immunologic diseases
allergy
underground construction
rock mechanics
soil mechanics
clamped plate problem
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