il-10 regulates adult neurogenesis by modulating erk and stat3 activity
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2015
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Abstract
The adult SVZ contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that IL-10 regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and modulating cell cycle exit. Here we addressed the specific mechanism through which IL-10 carries out its signaling on SVZ progenitors. We found that, in vitro and in vivo, IL-10 targets Nestin+ progenitors and activates the phosphorylation of ERK and STAT3. The action of IL-10 on Nestin+ progenitors is reversed by treatment with a MEK/ERK inhibitor, thus restoring neurogenesis to normal levels. Silencing STAT3 expression by lentiviral vectors also impaired neurogenesis by blocking the effects of IL-10. Our findings unveil ERK and STAT3 as effectors of IL-10 in adult SVZ neurogenesis.| Reference Key |
epereira2015frontiersil-10
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| Authors | ;Leticia ePereira;Miriam eFont-Nieves;Chris eVandenhaute;Veerle eBaekelandt;Anna M. ePlanas;Esther ePozas |
| Journal | macromolecular bioscience |
| Year | 2015 |
| DOI | 10.3389/fncel.2015.00057 |
| URL | |
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