Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives

Clicks: 319
ID: 119801
1995
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Abstract
A variety of imidazo[1,5-a]-1,3,5-triazine derivatives carrying C-, O-, and S-benzyl and/or 4-methylbenzyl groups were synthesized and examined for their inhibitory effects on the replication of ortho- and paramyxoviruses. The key compounds 8-R-2-thioxo-2,3-dihydroimidazo [1,5-a]-1,3,5-triazin-4(1H) ā€¦
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Authors Golankiewicz B;Januszczyk P;Ikeda S;Balzarini J;De Clercq E;;
Journal Journal of medicinal chemistry
Year 1995
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/7658442
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line chlorocebus aethiops vero cells e de clercq antiviral agents / pharmacology* hela cells hiv-1 / drug effects hiv-2 / drug effects human / drug effects respiratory syncytial viruses / drug effects structure-activity relationship parainfluenza virus 3 influenza a virus / drug effects pmid:7658442 doi:10.1021/jm00018a015 b golankiewicz p januszczyk antiviral agents / chemical synthesis drug screening assays antitumor imidazoles / chemical synthesis imidazoles / pharmacology* rna viruses / drug effects triazines / chemical synthesis triazines / pharmacology*

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