Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

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ID: 119028
2017
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Abstract
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on treatment of symptoms. Hyperandrogenism is the mo ā€¦
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Authors Caldwell ASL;Edwards MC;Desai R;Jimenez M;Gilchrist RB;Handelsman DJ;Walters KA;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2017
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/28320971
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Disease Models animal* Cells Cultured Receptors Knockout polycystic ovary syndrome / metabolism polycystic ovary syndrome / pathology* neurons / drug effects neurons / metabolism androgens / pharmacology* melissa c edwards kirsty a walters pmid:28320971 pmc5402450 doi:10.1073/pnas.1616467114 aimee s l caldwell estrous cycle / drug effects granulosa cells / drug effects granulosa cells / metabolism granulosa cells / pathology* neurons / pathology* neurosecretory systems / drug effects* polycystic ovary syndrome / drug therapy androgen / physiology*

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