PPAR gamma is required for placental, cardiac, and adipose tissue development

Clicks: 327
ID: 117001
1999
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Abstract
The nuclear hormone receptor PPAR gamma promotes adipogenesis and macrophage differentiation and is a primary pharmacological target in the treatment of type II diabetes. Here, we show that PPAR gamma gene knockout results in two independent lethal phases. Initially, PPAR gamma deficiency interferes ā€¦
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Authors Barak Y;Nelson MC;Ong ES;Jones YZ;Ruiz-Lozano P;Chien KR;Koder A;Evans RM;;
Journal molecular cell
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10549290
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Genes Receptors Liver / pathology Knockout adipose tissue / growth & development* gene targeting / methods in situ hybridization messenger / metabolism cytoplasmic and nuclear / genetics* cytoplasmic and nuclear / metabolism transcription factors / genetics* transcription factors / metabolism nuclear proteins / metabolism developmental cell differentiation / genetics fetal viability / genetics reporter nuclear proteins / genetics pmid:10549290 doi:10.1016/s1097-2765(00)80209-9 y barak m c nelson r m evans heart / growth & development* lipodystrophy / genetics myocardium / cytology myocardium / ultrastructure placenta / cytology placenta / ultrastructure placentation* ploidies retinoic acid / genetics retinoid x receptors

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