Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse

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ID: 116735
1997
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Abstract
The small hydrophobic protein SH of human respiratory syncytial virus (RSV) is a short transmembrane surface protein of unknown function. A full-length cDNA of RSV strain A2 (subgroup A) antigenomic RNA was modified such that the entire SH gene, including the transcription signals and the complete m ā€¦
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Authors Bukreyev A;Whitehead SS;Murphy BR;Collins PL;;
Journal Journal of Virology
Year 1997
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9371553
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice RNA animals humans pubmed abstract nih national institutes of health national library of medicine Cultured Antigens cell line DNA polymerase chain reaction recombination Inbred BALB C Base Sequence Viral Molecular Sequence Data Viral Proteins / genetics cattle virus replication viral / immunology hn protein* p l collins blotting chlorocebus aethiops vero cells respiratory syncytial virus viral proteins / immunology human / genetics intranasal tumor cells viral / genetics precipitin tests northern viral plaque assay viral proteins / physiology* human / growth & development pmid:9371553 pmc230197 doi:10.1128/jvi.71.12.8973-8982.1997 a bukreyev s s whitehead gene deletion giant cells / virology messenger human / physiology* respiratory system / virology viral envelope proteins / genetics viral envelope proteins / physiology*

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